A Review Of rheumatoid arthritis ppt

In the world, more and more and more people are suffering from the failure of their immune systems to distinguish between healthy cells or invaders microscopic organisms. Their organs and tissue are now being attacked by disease defences that they once had.




International research is being undertaken to combat the growing trend. This is a London-based initiative. Francis Crick Institute where two world experts, James Lee, and Carola Vinuesa, have formed distinct research groups to determine the root causes of autoimmune diseases.


Lee stated that cases of autoimmune disease are on the rise since around 40 years ago in the West. But, the diseases are now being seen in nations that haven't seen them before.


The Middle East and East Asia have seen the highest increase in cases of inflammatory bowel diseases. The people there had never heard of the disease prior to.


Type 1 diabetes is among the autoimmune diseases. Other ailments include rheumatoid disease, inflammatory bowel and multiple sclerosis. In all instances the immune system is activated and begins to turn on healthy tissues.


In the UK alone, more than 4 million people are suffering from such conditions, with some sufferers suffering from more than one. Internationally, it is now thought that cases of autoimmune diseases are growing between 3% and 9 percent per year. Researchers believe that environmental triggers play a major role in this rise.


Lee, who previously worked at Cambridge University, said that the human genetic makeup hasn't changed in the last decade. There must be a change in the outside world in a manner that's increasing our susceptibility to an autoimmune disorder.


Vinuesa was in favor of the idea, she was a former employee at the Australian National University. She noted that there had been changes in diet when more people ate western meals and increased consumption of fast food.


Vinuesa noted that fast-food dishes lack some important ingredients such as fiber. The evidence suggests that this can affect a person's microbiome, which is the collection of microorganisms in our digestive tract. Microorganisms play a important role in controlling a variety of bodily functions.


These changes to our microbiomes can cause autoimmune diseases There are more than 100 kinds.


Both scientists highlighted the importance of individual susceptibilities in acquiring such diseases. Celiac disease and Lupus are two additional conditions that can cause inflammation and swelling that can cause damage to different organs, including your heart.


"If you don't possess a particular genetic susceptibility it is unlikely that you will develop an autoimmune disease, no matter the amount of Big Macs you consume," said Vinuesa. There is no way to stop the proliferation of fast-food establishments across the globe. Therefore we're working to unravel the genetic causes that cause autoimmune diseases and make some people more susceptible than others. "We are trying to address the issue on a fundamental level."


Because of the advancement of technology, scientists are now able to find small differences in people's DNA. It is possible to determine common genetic patterns among people who suffer from an autoimmune disease.


Lee claims that, although we had tools for sequencing DNA to the point of being able to sequence DNA, until recent however, it was not possible. When I first began my research, we only knew about half of the DNA variations that were implicated in triggering inflammation in the intestines. Now, we know over 250.


Lee and Vinuesa have a particular focus of their efforts on this particular type of research. They want to learn more about genetic pathway and find the causes of the diverse diseases they study. Vinuesa said there could be multiple versions of certain autoimmune disorders, like Lupus. And that has a consequence when you are trying to determine the best treatment.


There are numerous effective new therapies in development, we don't yet know the people they ought to be offered to. This is because we don't really know the exact type of their condition. This is the reason why research on autoimmune disease has become a priority. In order to provide the appropriate treatment, we Click here have to understand how to classify patients.


Lee stated that the growing prevalence of autoimmune diseases across the globe meant that new treatment and drugs were urgently required. Lee said that at present there's no cure for autoimmune disorders. They typically occur in young adults who are trying to complete their education and get a job.


This means that a growing amount of people need surgery or need regular injections for the rest of their lives. It can be very distressing for patients and put stressing the health care system. We need new and effective treatment methods.


Rheumatoid arthritis is an immuno-mediated disorder. It's a mystery.


The immune system naturally produces antibodies to fight bacteria and viruses.


If you suffer from Rheumatoid arthritis, your immune systems mistakenly transmits antibodies to your joints' lining, where they target the tissues around them.


This causes the thin cell-like layer covering your joints (synovium), to become sore and inflamed, which releases arthritis rheumatoides seropositiva chemicals that cause harm nearby.


bones

Cartilage – The connective tissue that is stretchy and connects bones

Tendons, the tissue connecting bone to muscle

Ligaments are the connective tissue that connects cartilage and bone.

If rheumatoid doesn't get treated it will cause the joint lose its shape. It could eventually cause the destruction of the joint.


There have been a variety of theories on how the immune system fights the joints. One theory is that an infection might be a trigger. However, none of these theories has been confirmed.

Possible risk factors

There are a variety of factors that increase the risk of developing rheumatoid arthritis for example:


Genes. There are some indications that rheumatoid-related arthritis could run in families. However, since genes play only a small part in the condition's development, there is little risk of the disease being transferred to the next generation.

The condition is more prevalent among women than males. This may be due to estrogen effects, but this has not been proved.

Smoking is a risk factor. Some research suggests that smokers are at greater risk for developing rheumatoid arthritis.